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KMID : 0370220010450060730
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Yakhak Hoeji
2001 Volume.45 No. 6 p.730 ~ p.738
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Effect of the Water Extract of Albizzia julibrissin on Apoptotic Cell Death in the Human Leukemic Jurkat T Cell Line
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황상구/Hwang SG
이형철/김준관/김용익/주성민/김원신/전병훈/Lee HC/Kim CK/Kim YK/Ju SM/Kim WS/Jeon BH
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Abstract
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Apoptosis is a morphologically and biochemically distinct form of cell death that occurs in many different cell types in a wide variety of organisms. Albizzia julibrissin belonging the family Leguminosae has been used for the treatment of confusion, sore throat, amnesia, and insomnia in oriental traditional medicine. This study investigates whether the water extract of A. julibrissin induce apoptotic cell death in Jurkat T-acute Iymphoblastic leukemia (ALL) cells. Jurkat cells were increased inhibitions of cell viability in a concentration-dependent manner by A. julibrissin. This herbal medicine also caused apoptosis as measured by cell morphology and DNA fragmentation. The capability of A. julibrissin to induce apoptosis was associated with proteolytic cleavage of specific target protein such as poly (ADP-ribose) polymerase (PARP) protein suggesting the possible involvement of caspases. Our result showed that Bcl-2 and Bax protein levels were not changed in all A. julibrissin-treated groups compared to control group. These results suggest that A. julibrissin-mediated apoptosis is independent; with Bcl-2 related signaling pathway in this cells.
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